Sequences and topology: intrinsic disorder in the evolving universe of protein structure.

Julian Gough studied protein structure analysis; then combined it with sequence comparison methods to produce a bioinformatics resource mapping all known structural domains to all completely sequenced genomes. This resource has provided the data for him, his colleagues and others in the field to understand the evolution of the protein repertoire. To compare and contrast structured and disordered proteins, we collected some reviews on each topic, including reviews that consider evolutionary aspects of these proteins. On the structured side, the sequence ! structure ! function view dominates thinking about these proteins. The first two reviews are riveted deeply into this view of the protein world.